Meadow Creek is located in the upper region of the Memramcook River Watershed, and has an area of 38 km². The creek bed is mainly characterized as rocky with some sections having a higher sand content. The environment surrounding Meadow Creek is predominantly wooded, with some forestry activity.

Much of Meadow Creek flows adjacent to Route 2 and as a result experiences some fluctuations in water quality related to road runoff. It is important to note that the sampling location in Meadow Creek is downstream of a culvert outfall that is occasionally stagnant due to backflow, leading to lower dissolved oxygen levels.

Site Name: Meadow Brook @ Route 132
Site Code: MdC
Coordinates:46.09829, -64.58731